Trial literature on tumours of the central nervous system (CNS)

Literature on trials concerning medulloblastoma and other CNS-PNET, pineoblastoma, ependymoma, low-grade glioma, high-grade glioma, choroid plexus tumours, and craniopharyngioma

Medulloblastoma, CNS-PNET, pineoblastoma, ependymoma

Literature on medulloblastoma, supratentorial PNET (CNS-PNET, pineoblastoma, and ependymoma

 Search PubMed for recently published articles (external information service)
  1. Sabel M, Fleischhack G, Tippelt S, Gustafsson G, Doz F, Kortmann R, Massimino M, Navajas A, von Hoff K, Rutkowski S, Warmuth-Metz M, Clifford SC, Pietsch T, Pizer B, Lannering B, SIOP-E Brain Tumour Group: Relapse patterns and outcome after relapse in standard risk medulloblastoma: a report from the HIT-SIOP-PNET4 study. Journal of neuro-oncology 2016, [PMID: 27423645]
  2. Ottensmeier H, Zimolong B, Wolff JE, Ehrich J, Galley N, von Hoff K, Kuehl J, Rutkowski S: Neuropsychological short assessment of disease- and treatment-related intelligence deficits in children with brain tumours. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 2015, Epub ahead of print [PMID: 25617910]
  3. Friedrich C, Warmuth-Metz M, von Bueren AO, Nowak J, Bison B, von Hoff K, Pietsch T, Kortmann RD, Rutkowski S: Primitive neuroectodermal tumors of the brainstem in children treated according to the HIT trials: clinical findings of a rare disease. Journal of neurosurgery. Pediatrics 2015, 1 [PMID: 25555122]
  4. Gerber NU, Mynarek M, von Hoff K, Friedrich C, Resch A, Rutkowski S: Recent developments and current concepts in medulloblastoma. Cancer treatment reviews 2014, 40: 356 [PMID: 24389035]
  5. Kennedy C, Bull K, Chevignard M, Culliford D, Dörr HG, Doz F, Kortmann RD, Lannering B, Massimino M, Navajas Gutiérrez A, Rutkowski S, Spoudeas HA, Calaminus G, PNET4 study group of the Brain Tumour Group of The European branch of the International Society of Paediatric Oncology (SIOP-E): Quality of survival and growth in children and young adults in the PNET4 European controlled trial of hyperfractionated versus conventional radiation therapy for standard-risk medulloblastoma. International journal of radiation oncology, biology, physics 2014, 88: 292 [PMID: 24239386]
  6. Goschzik T, Zur Mühlen A, Kristiansen G, Haberler C, Stefanits H, Friedrich C, von Hoff K, Rutkowski S, Pfister SM, Pietsch T: Molecular stratification of medulloblastoma: Comparison of histological and genetic methods to detect Wnt activated tumors. Neuropathology and applied neurobiology 2014, [PMID: 24894640]
  7. Pietsch T, Schmidt R, Remke M, Korshunov A, Hovestadt V, Jones DT, Felsberg J, Kaulich K, Goschzik T, Kool M, Northcott PA, von Hoff K, von Bueren AO, Friedrich C, Mynarek M, Skladny H, Fleischhack G, Taylor MD, Cremer F, Lichter P, Faldum A, Reifenberger G, Rutkowski S, Pfister SM: Prognostic significance of clinical, histopathological, and molecular characteristics of medulloblastomas in the prospective HIT2000 multicenter clinical trial cohort. Acta neuropathologica 2014, 128: 137 [PMID: 24791927]
  8. Gerber NU, von Hoff K, Resch A, Ottensmeier H, Kwiecien R, Faldum A, Matuschek C, Hornung D, Bremer M, Benesch M, Pietsch T, Warmuth-Metz M, Kuehl J, Rutkowski S, Kortmann RD: Treatment of children with central nervous system primitive neuroectodermal tumors/pinealoblastomas in the prospective multicentric trial HIT 2000 using hyperfractionated radiation therapy followed by maintenance chemotherapy. International journal of radiation oncology, biology, physics 2014, 89: 863 [PMID: 24969797]
  9. Nowak J, Seidel C, Pietsch T, Friedrich C, von Hoff K, Rutkowski S, Warmuth-Metz M: Ependymoblastoma of the brainstem: MRI findings and differential diagnosis. Pediatric blood & cancer 2014, 61: 1132 [PMID: 24464920]
  10. Bode U, Zimmermann M, Moser O, Rutkowski S, Warmuth-Metz M, Pietsch T, Kortmann RD, Faldum A, Fleischhack G: Treatment of recurrent primitive neuroectodermal tumors (PNET) in children and adolescents with high-dose chemotherapy (HDC) and stem cell support: results of the HITREZ 97 multicentre trial. Journal of neuro-oncology 2014, 120: 635 [PMID: 25179451]
  11. Gessi M, von Bueren AO, Treszl A, Mühlen AZ, Hartmann W, Warmuth-Metz M, Rutkowski S, Pietsch T: MYCN amplification predicts poor outcome for patients with supratentorial primitive neuroectodermal tumors of the central nervous system. Neuro-oncology 2014, [PMID: 24470553]
  12. Remke M, Hering E, Gerber NU, Kool M, Sturm D, Rickert CH, Gerß J, Schulz S, Hielscher T, Hasselblatt M, Jeibmann A, Hans V, Ramaswamy V, Taylor MD, Pietsch T, Rutkowski S, Korshunov A, Monoranu CM, Frühwald MC: Somatostatin receptor subtype 2 (sst2) is a potential prognostic marker and a therapeutic target in medulloblastoma. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2013, 29: 1253 [PMID: 23677175]
  13. Friedrich C, von Bueren AO, von Hoff K, Gerber NU, Ottensmeier H, Deinlein F, Benesch M, Kwiecien R, Pietsch T, Warmuth-Metz M, Faldum A, Kuehl J, Kortmann RD, Rutkowski S: Treatment of young children with CNS-primitive neuroectodermal tumors/pineoblastomas in the prospective multicenter trial HIT 2000 using different chemotherapy regimens and radiotherapy. Neuro-oncology 2013, 15: 224 [PMID: 23223339]
  14. Hagel C, Treszl A, Fehlert J, Harder J, von Haxthausen F, Kern M, von Bueren AO, Kordes U: Supra- and infratentorial pediatric ependymomas differ significantly in NeuN, p75 and GFAP expression. Journal of neuro-oncology 2013, 112: 191 [PMID: 23371454]
  15. von Bueren AO, Bacolod MD, Hagel C, Heinimann K, Fedier A, Kordes U, Pietsch T, Koster J, Grotzer MA, Friedman HS, Marra G, Kool M, Rutkowski S: Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours. British journal of cancer 2012, 107: 1399-408 [PMID: 22976800]
  16. Lannering B, Rutkowski S, Doz F, Pizer B, Gustafsson G, Navajas A, Massimino M, Reddingius R, Benesch M, Carrie C, Taylor R, Gandola L, Björk-Eriksson T, Giralt J, Oldenburger F, Pietsch T, Figarella-Branger D, Robson K, Forni M, Clifford SC, Warmuth-Metz M, von Hoff K, Faldum A, Mosseri V, Kortmann R: Hyperfractionated versus conventional radiotherapy followed by chemotherapy in standard-risk medulloblastoma: results from the randomized multicenter HIT-SIOP PNET 4 trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012 Sep 10; 30: 3187 [PMID: 22851561]
  17. Müller K, Zwiener I, Welker H, Maaß E, Bongartz R, Berthold F, Pietsch T, Warmuth-Metz M, von Bueren A, Rutkowski S: Curative treatment for central nervous system medulloepithelioma despite residual disease after resection : Report of two cases treated according to the GPHO protocol HIT 2000 and review of the literature. Strahlentherapie und Onkologie 2011,Epub ahead of print [PMID: 22037651]
  18. von Bueren AO, von Hoff K, Pietsch T, Gerber NU, Warmuth-Metz M, Deinlein F, Zwiener I, Faldum A, Fleischhack G, Benesch M, Krauss J, Kuehl J, Kortmann RD, Rutkowski S: Treatment of young children with localized medulloblastoma by chemotherapy alone: results of the prospective, multicenter trial HIT 2000 confirming the prognostic impact of histology. Neuro Oncol 2011, 13: 669 [PMID: 21636711]
  19. Gerber NU, von Hoff K, von Bueren AO, Treulieb W, Deinlein F, Benesch M, Zwiener I, Soerensen N, Warmuth-Metz M, Pietsch T, Mittler U, Kuehl J, Kortmann RD, Grotzer MA, Rutkowski S: A long duration of the prediagnostic symptomatic interval is not associated with an unfavourable prognosis in childhood medulloblastoma. European journal of cancer 2011, [Epub ahead of print] [PMID: 22153558]
  20. Seifert G, Rutkowski S, Jesse P, Madeleyn R, Reif M, Henze G, Längler A: 2. Anthroposophic Supportive Treatment in Children With Medulloblastoma Receiving First-line Therapy. J Pediatr Hematol Oncol 2011, Epub ahead of print [PMID: 21368673]
  21. von Bueren AO, Warmuth-Metz M, Schlegel PG, Soerensen N, Krauss J, Roggendorf W, Pietsch T, Feiden W, Graf N, Pohl F, Flentje M, Kuehl J, Rutkowski S: Late complete remission of supratentorial primitive neuroectodermal tumor (CNS-PNET) after multiple relapses. Pediatr Blood Cancer 2011, 56: 503 [PMID: 21113945]
  22. Gerber NU, von Hoff K, von Bueren AO, Treulieb W, Warmuth-Metz M, Pietsch T, Soerensen N, Faldum A, Emser A, Schlegel PG, Deinlein F, Kortmann RD, Rutkowski S: Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006. J Neurooncol 2011, 102: 459 [PMID: 21308398]
  23. Seifert G, Kanitz JL, Pretzer K, Henze G, Witt K, Reulecke S, Voss A: Improvement of Heart Rate Variability by Eurythmy Therapy After a 6-Week Eurythmy Therapy Training. Integr Cancer Ther 2011, [Epub ahead of print] [PMID: 21733984]
  24. von Bueren AO, von Hoff K, Pietsch T, Gerber NU, Warmuth-Metz M, Deinlein F, Zwiener I, Faldum A, Fleischhack G, Benesch M, Krauss J, Kuehl J, Kortmann RD, Rutkowski S: Treatment of young children with localized medulloblastoma by chemotherapy alone: results of the prospective, multicenter trial HIT 2000 confirming the prognostic impact of histology. Neuro-oncology 2011, 13: 669 [PMID: 21636711]
  25. Rutkowski S, Cohen B, Finlay J, Luksch R, Ridola V, Valteau-Couanet D, Hara J, Garre ML, Grill J: Medulloblastoma in young children. Pediatr Blood Cancer 2010, 54: 635 [PMID: 20146217]
  26. Benesch M, Weber-Mzell D, Gerber NU, von Hoff K, Deinlein F, Krauss J, Warmuth-Metz M, Kortmann RD, Pietsch T, Driever PH, Quehenberger F, Urban C, Rutkowski S: Ependymoma of the spinal cord in children and adolescents: a retrospective series from the HIT database. J Neurosurg Pediatr 2010, 6: 137 [PMID: 20672934]
  27. Rutkowski S, von Hoff K, Emser A, Zwiener I, Pietsch T, Figarella-Branger D, Giangaspero F, Ellison DW, Garre ML, Biassoni V, Grundy RG, Finlay JL, Dhall G, Raquin MA, Grill J: Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis. J Clin Oncol 2010, 28: 4961 [PMID: 20940197]
  28. Warmuth-Metz M, Blashofer S, von Bueren AO, von Hoff K, Bison B, Pohl F, Kortmann RD, Pietsch T, Rutkowski S: Recurrence in childhood medulloblastoma. J Neurooncol 2010, Epub ahead of print] [PMID: 21069427]
  29. Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S: Childhood medulloblastoma. Crit Rev Oncol Hematol 2010, Epub ahead of print [PMID: 21129995]
  30. Benesch M, Sperl D, von Bueren AO, Schmid I, von Hoff K, Warmuth-Metz M, Ferrari R, Lassay L, Kortmann RD, Pietsch T, Rutkowski S: Primary central nervous system primitive neuroectodermal tumors (CNS-PNETs) of the spinal cord in children: four cases from the German HIT database with a critical review of the literature. J Neurooncol 2010, Epub ahead of print [PMID: 21181235]
  31. von Hoff K, Hartmann W, von Bueren AO, Gerber NU, Grotzer MA, Pietsch T, Rutkowski S: Large cell/anaplastic medulloblastoma: outcome according to myc status, histopathological, and clinical risk factors. Pediatric blood & cancer 2010, 54: 369 [PMID: 19908297]
  32. Ardon H, De Vleeschouwer S, Van Calenbergh F, Claes L, Kramm CM, Rutkowski S, Wolff JE, Van Gool SW: Adjuvant dendritic cell-based tumour vaccination for children with malignant brain tumours. Pediatric blood & cancer 2010, 54: 519 [PMID: 19852061]
  33. Rutkowski S, Gerber NU, von Hoff K, Gnekow A, Bode U, Graf N, Berthold F, Henze G, Wolff JE, Warmuth-Metz M, Soerensen N, Emser A, Ottensmeier H, Deinlein F, Schlegel PG, Kortmann RD, Pietsch T, Kuehl J, German Pediatric Brain Tumor Study Group: Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy. Neuro-oncology 2009, 11: 201 [PMID: 18818397]
  34. Benesch M, Siegler N, Hoff K, Lassay L, Kropshofer G, Müller H, Sommer C, Rutkowski S, Fleischhack G, Urban C: Safety and toxicity of intrathecal liposomal cytarabine (Depocyte) in children and adolescents with recurrent or refractory brain tumors: a multi-institutional retrospective study. Anti-cancer drugs 2009, 20: 794 [PMID: 19617818]
  35. Rutkowski S, Riehle E: Access to employment and economic independence in cerebral palsy. Physical medicine and rehabilitation clinics of North America 2009, 20: 535 [PMID: 19643352]
  36. von Hoff K, Hinkes B, Gerber NU, Deinlein F, Mittler U, Urban C, Benesch M, Warmuth-Metz M, Soerensen N, Zwiener I, Goette H, Schlegel PG, Pietsch T, Kortmann RD, Kuehl J, Rutkowski S: Long-term outcome and clinical prognostic factors in children with medulloblastoma treated in the prospective randomised multicentre trial HIT'91. European journal of cancer (Oxford, England : 1990) 2009, 45: 1209 [PMID: 19250820]
  37. Pfister S, Remke M, Benner A, Mendrzyk F, Toedt G, Felsberg J, Wittmann A, Devens F, Gerber NU, Joos S, Kulozik A, Reifenberger G, Rutkowski S, Wiestler OD, Radlwimmer B, Scheurlen W, Lichter P, Korshunov A: Outcome prediction in pediatric medulloblastoma based on DNA copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci. Journal of clinical oncology 2009, 27: 1627 [PMID: 19255330]
  38. von Bueren AO, von Hoff K, Benesch M, Rutkowski S: Dose reductions of vincristine in children with medulloblastoma treated in the maintenance arm of the prospective multicenter trial HIT'91. Klinische Padiatrie 2009, 221: 396 [PMID: 19890797]
  39. Rutkowski S, von Bueren A, von Hoff K, Hartmann W, Shalaby T, Deinlein F, Warmuth-Metz M, Soerensen N, Emser A, Bode U, Mittler U, Urban C, Benesch M, Kortmann RD, Schlegel PG, Kuehl J, Pietsch T, Grotzer M: Prognostic relevance of clinical and biological risk factors in childhood medulloblastoma: results of patients treated in the prospective multicenter trial HIT'91. Clinical cancer research 2007, 13: 2651 [PMID: 17473196]
  40. Grotzer MA, von Hoff K, von Bueren AO, Shalaby T, Hartmann W, Warmuth-Metz M, Emser A, Kortmann RD, Kuehl J, Pietsch T, Rutkowski S: Which clinical and biological tumor markers proved predictive in the prospective multicenter trial HIT'91--implications for investigating childhood medulloblastoma. Klinische Padiatrie 2007, 219: 312 [PMID: 18050040]
  41. Rutkowski S: Timely identification of suspected paediatric CNS tumours. The lancet oncology 2007, 8: 664 [PMID: 17679075]
  42. Timmermann B, Kortmann RD, Kühl J, Rutkowski S, Meisner C, Pietsch T, Deinlein F, Urban C, Warmuth-Metz M, Bamberg M: Role of radiotherapy in supratentorial primitive neuroectodermal tumor in young children: results of the German HIT-SKK87 and HIT-SKK92 trials. Journal of clinical oncology 2006, 24: 1554 [PMID: 16575007]
  43. Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, Soerensen N, Graf N, Emser A, Pietsch T, Wolff JE, Kortmann RD, Kuehl J: Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. The New England journal of medicine 2005, 352: 978 [PMID: 15758008]
  44. Timmermann B, Kortmann RD, Kühl J, Rutkowski S, Dieckmann K, Meisner C, Bamberg M: Role of radiotherapy in anaplastic ependymoma in children under age of 3 years: results of the prospective German brain tumor trials HIT-SKK 87 and 92. Radiotherapy and oncology 2005, 77: 278 [PMID: 16300848]
  45. Kortmann RD, Timmermann B, Rutkowski S, Bamberg M: Re: B. Beuthien-Baumann, et al. Differentiation between recurrent tumor and radiation necrosis in a child with anaplastic ependymoma after chemotherapy and radiation therapy. Strahlenther Onkol 2003;179:819-22. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]. 2004, 180: 245 [PMID: 15057436]
  46. Scheurlen WG, Schwabe GC, Joos S, Mollenhauer J, Sörensen N, Kühl J: Molecular analysis of childhood primitive neuroectodermal tumors defines markers associated with poor outcome. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998, 16: 2478 [PMID: 9667267]
  47. Scheurlen W, Kühl J: Current diagnostic and therapeutic management of CNS metastasis in childhood primitive neuroectodermal tumors and ependymomas. Journal of neuro-oncology 1998, 38(2-3): 181 [PMID: 9696369]
  48. Scheurlen WG, Seranski P, Mincheva A, Kühl J, Sörensen N, Krauss J, Lichter P, Poustka A, Wilgenbus KK: High-resolution deletion mapping of chromosome arm 17p in childhood primitive neuroectodermal tumors reveals a common chromosomal disruption within the Smith-Magenis region, an unstable region in chromosome band 17p11. 2. Genes, chromosomes & cancer 1997, 18: 50 [PMID: 8993980]

Low-grade glioma

Literature on low grade glioma (LGG)

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  1. Mirow C, Pietsch T, Berkefeld S, Kwiecien R, Warmuth-Metz M, Falkenstein F, Diehl B, von Hornstein S, Gnekow AK: Children <1 year show an inferior outcome when treated according to the traditional LGG treatment strategy: a report from the German multicenter trial HIT-LGG 1996 for children with low grade glioma (LGG). Pediatric blood & cancer 2014, 61: 457 [PMID: 24039013]
  2. Müller K, Gnekow A, Falkenstein F, Scheiderbauer J, Zwiener I, Pietsch T, Warmuth-Metz M, Voges J, Nikkhah G, Flentje M, Combs SE, Vordermark D, Kocher M, Kortmann RD: Radiotherapy in pediatric pilocytic astrocytomas : A subgroup analysis within the prospective multicenter study HIT-LGG 1996 by the German Society of Pediatric Oncology and Hematology (GPOH). Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 2013, 189: 647 [PMID: 23831852]
  3. Gnekow AK, Falkenstein F, von Hornstein S, Zwiener I, Berkefeld S, Bison B, Warmuth-Metz M, Driever PH, Soerensen N, Kortmann RD, Pietsch T, Faldum A: Long-term follow-up of the multicenter, multidisciplinary treatment study HIT-LGG-1996 for low-grade glioma in children and adolescents of the German Speaking Society of Pediatric Oncology and Hematology. Neuro-oncology 2012, 14: 1265 [PMID: 22942186]
  4. Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C, Pfaff E, Tönjes M, Sill M, Bender S, Kool M, Zapatka M, Becker N, Zucknick M, Hielscher T, Liu XY, Fontebasso AM, Ryzhova M, Albrecht S, Jacob K, Wolter M, Ebinger M, Schuhmann MU, van Meter T, Frühwald MC, Hauch H, Pekrun A, Radlwimmer B, Niehues T, von Komorowski G, Dürken M, Kulozik AE, Madden J, Donson A, Foreman NK, Drissi R, Fouladi M, Scheurlen W, von Deimling A, Monoranu C, Roggendorf W, Herold-Mende C, Unterberg A, Kramm CM, Felsberg J, Hartmann C, Wiestler B, Wick W, Milde T, Witt O, Lindroth AM, Schwartzentruber J, Faury D, Fleming A, Zakrzewska M, Liberski PP, Zakrzewski K, Hauser P, Garami M, Klekner A, Bognar L, Morrissy S, Cavalli F, Taylor MD, van Sluis P, Koster J, Versteeg R, Volckmann R, Mikkelsen T, Aldape K, Reifenberger G, Collins VP, Majewski J, Korshunov A, Lichter P, Plass C, Jabado N, Pfister SM: Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer cell 2012, 22: 425 [PMID: 23079654]
  5. Korinthenberg R, Neuburger D, Nikkhah G, Teske C, Schnabel K, Calaminus G: Assessing Quality of Life in Long-Term Survivors after 125I Brachytherapy for Low-Grade Glioma in Childhood. Neuropediatrics 2011, 42: 110 [PMID: 21739406]
  6. von Hornstein S, Kortmann RD, Pietsch T, Emser A, Warmuth-Metz M, Soerensen N, Straeter R, Graf N, Thieme B, Gnekow AK: Impact of chemotherapy on disseminated low-grade glioma in children and adolescents: report from the HIT-LGG 1996 trial. Pediatric blood & cancer 2011 Jul 1; 56: 1046 [PMID: 21319282]
  7. Hupp M, Falkenstein F, Bison B, Mirow C, Krauß J, Gnekow A, Solymosi L, Warmuth-Metz M: Infarction following chiasmatic low grade glioma resection. Child's nervous system 2011,Epub ahead of print [PMID: 21987345]
  8. Rokes CA, Remke M, Guha-Thakurta N, Witt O, Korshunov A, Pfister S, Wolff JE: Sorafenib plus valproic acid for infant spinal glioblastoma. J Pediatr Hematol Oncol 2010, 32: 511 [DOI: 20463608]
  9. Hernáiz Driever P, von Hornstein S, Pietsch T, Kortmann R, Warmuth-Metz M, Emser A, Gnekow AK: Natural history and management of low-grade glioma in NF-1 children. J Neurooncol 2010, [PMID: 20352473]
  10. Scheiderbauer J, Gnekow AK, Emser A, Hildebrandt G, Bamberg M, Kortmann RD: Multizentrische prospektive kooperative Studie SIOP/GPOH „Low grade glioma„ im Kindesalter von 1996: Ergebnisse nach Strahlentherapie (Deutschland). Strahlenther Onkol 2005, 181 (Sondernr 1): 39
  11. Gnekow AK, Scheiderbauer J, Pietsch T, Soerensen N, Faldum A, Emser A, von Hornstein S, Warmuth-Metz M, Kuehl J: HIT-LGG 1996-Success of a countrywide, comprehensive treatment strategy for children and adolescents with low grade glioma of all histologies and locations. Pedriatric Blood and Cancer 2005, 45: 465
  12. Gnekow AK, Kortmann RD, Pietsch T, Emser A: Low grade chiasmatic-hypothalamic glioma-carboplatin and vincristin chemotherapy effectively defers radiotherapy within a comprehensive treatment strategy -- report from the multicenter treatment study for children and adolescents with a low grade glioma -- HIT-LGG 1996 -- of the Society of Pediatric Oncology and Hematology (GPOH). Klinische Padiatrie 2004, 216: 331 [PMID: 15565548]
  13. Peters O, Gnekow AK, Rating D, Wolff JE: Impact of location on outcome in children with low-grade oligodendroglioma. Pediatric blood & cancer 2004, 43: 250 [PMID: 15266409]
  14. Peters U, Preisler-Adams S, Lanvers-Kaminsky C, Jürgens H, Lamprecht-Dinnesen A: Sequence variations of mitochondrial DNA and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Res 2003, 23: 1249

High-grade glioma / Glioblastoma

Literature on high grade gliomas (HGG) / Glioblastoma multiforme (GBM)

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  1. Müller K, Scheithauer H, Pietschmann S, Hoffmann M, Rössler J, Graf N, Baumert BG, Christiansen H, Kortmann RD, Kramm CM, von Bueren AO: Reirradiation as part of a salvage treatment approach for progressive non-pontine pediatric high-grade gliomas: preliminary experiences from the German HIT-HGG study group. Radiation oncology 2014, 9: 177 [PMID: 25112658]
  2. Müller K, Schlamann A, Seidel C, Warmuth-Metz M, Christiansen H, Vordermark D, Kortmann RD, Kramm CM, von Bueren AO: Craniospinal irradiation with concurrent temozolomide and nimotuzumab in a child with primary metastatic diffuse intrinsic pontine glioma : A compassionate use treatment. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 2013, 189: 693 [PMID: 23754473]
  3. Leonard A, Wolff JE: Etoposide Improves Survival in High-grade Glioma: A Meta-Analysis. Anticancer research 2013, 33: 3307 [PMID: 23898097]
  4. Gielen GH, Gessi M, Hammes J, Kramm CM, Waha A, Pietsch T: H3F3A K27M mutation in pediatric CNS tumors: a marker for diffuse high-grade astrocytomas. American journal of clinical pathology 2013, 139: 345 [PMID: 23429371]
  5. Karremann M, Rausche U, Roth D, Kühn A, Pietsch T, Gielen GH, Warmuth-Metz M, Kortmann RD, Straeter R, Gnekow A, Wolff JE, Kramm CM: Cerebellar location may predict an unfavourable prognosis in paediatric high-grade glioma. British journal of cancer 2013, epub ahead of print [PMID: 23868007]
  6. Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C, Pfaff E, Tönjes M, Sill M, Bender S, Kool M, Zapatka M, Becker N, Zucknick M, Hielscher T, Liu XY, Fontebasso AM, Ryzhova M, Albrecht S, Jacob K, Wolter M, Ebinger M, Schuhmann MU, van Meter T, Frühwald MC, Hauch H, Pekrun A, Radlwimmer B, Niehues T, von Komorowski G, Dürken M, Kulozik AE, Madden J, Donson A, Foreman NK, Drissi R, Fouladi M, Scheurlen W, von Deimling A, Monoranu C, Roggendorf W, Herold-Mende C, Unterberg A, Kramm CM, Felsberg J, Hartmann C, Wiestler B, Wick W, Milde T, Witt O, Lindroth AM, Schwartzentruber J, Faury D, Fleming A, Zakrzewska M, Liberski PP, Zakrzewski K, Hauser P, Garami M, Klekner A, Bognar L, Morrissy S, Cavalli F, Taylor MD, van Sluis P, Koster J, Versteeg R, Volckmann R, Mikkelsen T, Aldape K, Reifenberger G, Collins VP, Majewski J, Korshunov A, Lichter P, Plass C, Jabado N, Pfister SM: Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer cell 2012, 22: 425 [PMID: 23079654]
  7. Wolff JE, Rytting ME, Vats TS, Zage PE, Ater JL, Woo S, Kuttesch J, Ketonen L, Mahajan A: Treatment of recurrent diffuse intrinsic pontine glioma: the MD Anderson Cancer Center experience. Journal of neuro-oncology 2011,Epub ahead of print [PMID: 21858608]
  8. MacDonald TJ, Aguilera D, Kramm CM: Treatment of high-grade glioma in children and adolescents. Neuro Oncol 2011, [Epub ahead of print] [PMID: 21784756]
  9. Kramm CM, Butenhoff S, Rausche U, Warmuth-Metz M, Kortmann RD, Pietsch T, Gnekow A, Jorch N, Janssen G, Berthold F, Wolff JE: Thalamic high-grade gliomas in children: a distinct clinical subset? Neuro Oncol 2011, 13: 680 [PMID: 21636712]
  10. Wolff B, Ng A, Roth D, Parthey K, Warmuth-Metz M, Eyrich M, Kordes U, Kortmann R, Pietsch T, Kramm C, Wolff JE: Pediatric high grade glioma of the spinal cord: results of the HIT-GBM database. Journal of neuro-oncology 2011,Epub ahead of print [PMID: 21964697]
  11. Wolff JE, Mohiuddin K, Jorch N, Graf N, Wagner S, Vats T, Gnekow A: Measuring performance status in pediatric patients with brain tumors--experience of the HIT-GBM-C protocol. Pediatr Blood Cancer 2010, 55: 520 [PMID: 20658624]
  12. Rokes CA, Remke M, Guha-Thakurta N, Witt O, Korshunov A, Pfister S, Wolff JE: Sorafenib plus valproic acid for infant spinal glioblastoma. J Pediatr Hematol Oncol 2010, 32: 511 [DOI: 20463608]
  13. Wolff JE, Driever PH, Erdlenbruch B, Kortmann RD, Rutkowski S, Pietsch T, Parker C, Metz MW, Gnekow A, Kramm CM: Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol. Cancer 2010, 116: 705 [PMID: 19957326]
  14. Karremann M, Pietsch T, Janssen G, Kramm CM, Wolff JE: Anaplastic ganglioglioma in children. J Neurooncol 2009, 92: 157 [PMID: 19043777]
  15. Karremann M, Butenhoff S, Rausche U, Pietsch T, Wolff JE, Kramm CM: Pediatric giant cell glioblastoma: New insights into a rare tumor entity. Neuro-oncology 2009, 11: 323 [PMID: 19050301]
  16. Wolff JE, Classen CF, Wagner S, Kortmann RD, Palla SL, Pietsch T, Kühl J, Gnekow A, Kramm CM: Subpopulations of malignant gliomas in pediatric patients: analysis of the HIT-GBM database. J Neurooncol 2008, 87: 155 [PMID: 18209954]
  17. Wolff JE, Berrak S, Koontz Webb SE, Zhang M: Nitrosourea efficacy in high-grade glioma: a survival gain analysis summarizing 504 cohorts with 24193 patients. J Neurooncol 2008, 88: 57 [PMID: 18253699]
  18. Masoudi A, Elopre M, Amini E, Nagel ME, Ater JL, Gopalakrishnan V, Wolff JE: Influence of valproic acid on outcome of high-grade gliomas in children. Anticancer Res 2008, 28: 2437 [PMID: 18751431]
  19. Wolff JE, Kramm C, Kortmann RD, Pietsch T, Rutkowski S, Jorch N, Gnekow A, Driever PH: Valproic acid was well tolerated in heavily pretreated pediatric patients with high-grade glioma. J Neurooncol 2008, 90: 309 [PMID: 18679579]
  20. Wagner S, Benesch M, Berthold F, Gnekow AK, Rutkowski S, Sträter R, Warmuth-Metz M, Kortmann RD, Pietsch T, Wolff JE: Secondary dissemination in children with high-grade malignant gliomas and diffuse intrinsic pontine gliomas. Br J Cancer 95: 991 [PMID: 17047647]
  21. Kramm CM, Wagner S, Van Gool S, Schmid H, Strater R, Gnekow A, Rutkowski S, Wolff JE: Improved survival after gross total resection of malignant gliomas in pediatric patients from the HIT-GBM studies. Anticancer Res 2006, 26: 3773 [PMID: 17094400]

Choroid plexus tumours

Literature on choroid plexus tumours

 Search PubMed for recently published articles (external information service)
  1. Ruland V, Hartung S, Kordes U, Wolff JE, Paulus W, Hasselblatt M: Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis. Genes, chromosomes & cancer 2014, 53: 373 [PMID: 24478045]
  2. Berrak SG, Liu DD, Wrede B, Wolff JE: Which therapy works better in choroid plexus carcinomas? J Neurooncol 2011, 103: 155 [PMID: 20976614]
  3. Mazloom A, Wolff JE, Paulino AC: The impact of radiotherapy fields in the treatment of patients with choroid plexus carcinoma. Int J Radiat Oncol Biol Phys 2010, 78: 79 [PMID: 20004534]
  4. Subbiah V, Ketonen L, Bruner JM, Nunez R, Weinberg J, Wolff JE: 99mTc-sestamibi scan differentiates tumor from other contrast enhancing tissue in choroid plexus tumors. J Clin Onco 2010, 32: 160 [PMID: 20168252]
  5. Berrak SG, Liu DD, Wrede B, Wolff JE: Which therapy works better in choroid plexus carcinomas? J Neurooncol 2010, Epub ahead of print [PMID: 20976614]
  6. Hasselblatt M, Mühlisch J, Wrede B, Kallinger B, Jeibmann A, Peters O, Kutluk T, Wolff JE, Paulus W, Frühwald MC: Aberrant MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation in choroid plexus tumors. J Neurooncol 2009, 91: 151 [PMID: 18795231]
  7. Prasad P, Vasquez H, Das CM, Gopalakrishnan V, Wolff JE: Histone acetylation resulting in resistance to methotrexate in choroid plexus cells. J Neurooncol 2009, 91: 279 [PMID: 18853233]
  8. Wrede B, Hasselblatt M, Peters O, Thall PF, Kutluk T, Moghrabi A, Mahajan A, Rutkowski S, Diez B, Wang X, Pietsch T, Kortmann RD, Paulus W, Jeibmann A, Wolff JE: Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. J Neurooncol 2009, 95: 383 [PMID: 19543851]
  9. Wrede B, Liu P, Wolff JE: Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors. J Neurooncol 2007, 85: 345 [PMID: 17576522]

Craniopharyngeoma

Trial literature on craniopharyngeoma

 Search PubMed for recently published articles (external information service)
  1. Hoffmann A, Warmth-Metz M, Gebhardt U, Pietsch T, Pohl F, Kortmann RD, Calaminus G, Müller HL: Childhood craniopharyngioma - changes of treatment strategies in the trials KRANIOPHARYNGEOM 2000/2007. Klinische Padiatrie 2014, 226: 161 [PMID: 24819386]
  2. Özyurt J, Thiel CM, Lorenzen A, Gebhardt U, Calaminus G, Warmuth-Metz M, Müller HL: Neuropsychological outcome in patients with childhood craniopharyngioma and hypothalamic involvement. The Journal of pediatrics 2014, 164: 876-881.e4 [PMID: 24507865]
  3. Hoffmann A, Gebhardt U, Sterkenburg A, Warmuth-Metz M, Müller HL: Diencephalic syndrome in childhood craniopharyngioma -Results of German multicentre studies on 485 long-term survivors of childhood craniopharyngioma. The Journal of clinical endocrinology and metabolism 2014,jc20141680 [PMID: 25077898]
  4. Ozyurt J, Lorenzen A, Gebhardt U, Warmuth-Metz M, Müller HL, Thiel CM: Remote effects of hypothalamic lesions in the prefrontal cortex of craniopharygioma patients. Neurobiology of learning and memory 2014, 111: 71 [PMID: 24662774]
  5. Müller HL: Paediatrics: Surgical strategy and quality of life in craniopharyngioma. Nature reviews. Endocrinology 2013, 9: 447 [PMID: 23797818]
  6. Müller HL, Gebhardt U, Faldum A, Warmuth-Metz M, Pietsch T, Pohl F, Calaminus G, Sörensen N, Kraniopharyngeom 2000 Study Committee: Xanthogranuloma, Rathke's cyst, and childhood craniopharyngioma: results of prospective multinational studies of children and adolescents with rare sellar malformations. The Journal of clinical endocrinology and metabolism 2012, 97: 3935 [PMID: 22969141]
  7. Kordes U, Flitsch J, Hagel C, Goebell E, Schwarz R, Herberhold T, von Bueren AO, Rutkowski S, Müller HL: Ectopic craniopharyngioma. Klin padiatr 2011, 223: 176 [PMID: 21462099]
  8. Müller HL: Consequences of craniopharyngioma surgery in children. J Clin Endocrinol Metab 2011, 96: 1981 [PMID: 21508127]
  9. Müller HL, Gebhardt U, Teske C, Faldum A, Zwiener I, Warmuth-Metz M, Pietsch T, Pohl F, Sörensen N, Calaminus G, the study committee of KRANIOPHARYNGEOM 2000: Post-operative hypothalamic lesions and obesity in childhood craniopharyngioma: results of the multinational prospective trial KRANIOPHARYNGEOM 2000 after 3-year follow-up. Eur J Endocrinol 2011, 165: 17 [PMID: 21490122]
  10. Müller HL, Gebhardt U, Schröder S, Pohl F, Kortmann RD, Faldum A, Zwiener I, Warmuth-Metz M, Pietsch T, Calaminus G, Kolb R, Wiegand C, Sörensen N, study committee of KRANIOPHARYNGEOM 2000/2007: Analyses of treatment variables for patients with childhood craniopharyngioma--results of the multicenter prospective trial KRANIOPHARYNGEOM 2000 after three years of follow-up. Horm Res Paediatr 2010, 73: 175 [PMID: 20197669]
  11. Müller HL: Childhood craniopharyngioma: current controversies on management in diagnostics, treatment and follow-up. Expert Rev Neurother 2010, 10: 515 [PMID: 20367205]
  12. Müller HL: Increased daytime sleepiness in patients with childhood craniopharyngioma and hypothalamic tumor involvement: review of the literature and perspectives. nt J Endocrinol 2010, 2010, 519607 [PMID: 21234339]
  13. Müller HL, Sörensen N: Kraniopharyngiom im Kindes- und Jugendalter. Interdisziplinäre Leitlinie der Deutschen Krebsgesellschaft und der Gesellschaft für Pädiatrische Onkologie und Hämatologie AWMF online 2008 [URI: http://www.awmf.org/ uploads/ tx_szleitlinien/ 025-026.pdf]
  14. Müller HL: Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow-up. Horm Res 2008, 69: 193 [PMID: 18204266]
  15. Roth CL, Hunneman DH, Gebhardt U, Stoffel-Wagner B, Reinehr T, Müller HL: Reduced sympathetic metabolites in urine of obese patients with craniopharyngioma. Pediatr Res 2007, 61: 496 [PMID: 17515878]
  16. Müller HL, Gebhardt U, Wessel V, Schröder S, Kolb R, Sörensen N, Maroske J, Hanisch E: First experiences with laparoscopic adjustable gastric banding (LAGB) in the treatment of patients with childhood craniopharyngioma and morbid obesity. Klin padiatr 2007, 219: 323-5. [PMID: 18050042]
  17. Müller HL, Albanese A, Calaminus G, Hargrave D, Garré ML, Gebhardt U, Saran F, Sörensen N, Spoudeas HA: Consensus and perspectives on treatment strategies in childhood craniopharyngioma: results of a meeting of the Craniopharyngioma Study Group (SIOP), Genova, 2004. J Pediatr Endocrinol Metab 2006, 19 Suppl 1: 453 [PMID: 16700324]
  18. Müller HL, Gebhardt U, Pohl F, Flentje M, Emser A, Warmuth-Metz M, Kolb R, Calaminus G, Sörensen N: Relapse pattern after complete resection and early progression after incomplete resection of childhood craniopharyngioma. Klin Pädiatr 2006, 218: 315-20. [PMID: 17080333]
  19. Müller H: Warum brauchen manche Hirntumorpatienten Hormone, obwohl ihre Drüsen gesund sind? WIR Informationsschrift der Aktion für krebskranke Kinder e.V. (Bonn) 2006, 2: 12 [URI: http://www.kinderkrebsstiftung.de/ fileadmin/ KKS/ files/ zeitschriftWIR/ 2006_2/ hormone.pdf]