New publications of GPOH-members

Acute Leukaemias

Risk of thromboembolism with ALL

  1. Mitchell L, Lambers M, Flege S, Kenet G, Li-Thiao-Te V, Holzhauer S, Bidlingmaier C, Frühwald MC, Heller C, Schmidt W, Pautard B, Nowak-Göttl U: Validation of a predictive model for identifying an increased risk for thromboembolism in children with acute lymphoblastic leukemia: results of a multicenter cohort study. Blood 2010, 115: 4999 [PMID: 20339086]

We would like to call your attention to the following article on the risk of thrombosis for patients with ALL by Ms. Prof. Nowak-Göttl. It is available online at Free Text online:

In the journal LEUKEMIA 24, February 2010, the long term results of the international paediatric ALL trials have been published:

Long-term results in the treatment of ALL

  1. Escherich G, Horstmann MA, Zimmermann M, Janka-Schaub GE, COALL study group: Cooperative study group for childhood acute lymphoblastic leukaemia (COALL): long-term results of trials 82,85,89,92 and 97. Leukemia : 2010, 24: 298 [PMID: 20016530]
  2. Schrappe M, Nachman J, Hunger S, Schmiegelow K, Conter V, Masera G, Pieters R, Pui CH: 'Educational symposium on long-term results of large prospective clinical trials for childhood acute lymphoblastic leukemia (1985-2000)'. Leukemia 2010, 24: 253 [PMID: 20145664]


  1. Conter V, Bartram CR, Valsecchi MG, Schrauder A, Panzer-Grümayer R, Möricke A, Aricò M, Zimmermann M, Mann G, De Rossi G, Stanulla M, Locatelli F, Basso G, Niggli F, Barisone E, Henze G, Ludwig WD, Haas OA, Cazzaniga G, Koehler R, Silvestri D, Bradtke J, Parasole R, Beier R, van Dongen JJ, Biondi A, Schrappe M: Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study. Blood 2010, 115: 3206 [PMID: 20154213]
  2. Klingebiel T, Cornish J, Labopin M, Locatelli F, Darbyshire P, Handgretinger R, Balduzzi A, Owoc-Lempach J, Fagioli F, Or R, Peters C, Aversa F, Polge E, Dini G, Rocha V, Pediatric Diseases and Acute Leukemia Working Parties of the European Group for Blood and Marrow Transplantation (EBMT): Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplantation in children with very high-risk acute lymphoblastic leukemia: impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric Disease Working Parties of the European Blood and Marrow Transplant group. Blood 2010, 115: 3437 [PMID: 20040760]
  3. Cario G, Zimmermann M, Romey R, Gesk S, Vater I, Harbott J, Schrauder A, Moericke A, Izraeli S, Akasaka T, Dyer MJ, Siebert R, Schrappe M, Stanulla M: Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol. Blood 2010, [PMID: 20378752]
  4. Stanulla M, Schaeffeler E, Möricke A, Coulthard SA, Cario G, Schrauder A, Kaatsch P, Dördelmann M, Welte K, Zimmermann M, Reiter A, Eichelbaum M, Riehm H, Schrappe M, Schwab M: Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols. Blood 2009, 114: 1314 [PMID: 19535798]

Publications concerning acute myeloic leukaemia (AML) and myelodysplastic syndrome (MDS):


  1. Sander A, Zimmermann M, Dworzak M, Fleischhack G, von Neuhoff C, Reinhardt D, Kaspers GJ, Creutzig U: Consequent and intensified relapse therapy improved survival in pediatric AML: results of relapse treatment in 379 patients of three consecutive AML-BFM trials. Leukemia 2010 [PMID: 20535146]
  2. Niewerth D, Creutzig U, Bierings MB, Kaspers GJ: A review on allogeneic stem cell transplantation for newly diagnosed pediatric acute myeloid leukemia. Blood 2010, [PMID: 20538803]
  3. von Neuhoff C, Reinhardt D, Sander A, Zimmermann M, Bradtke J, Betts DR, Zemanova Z, Stary J, Bourquin JP, Haas OA, Dworzak MN, Creutzig U: Prognostic Impact of Specific Chromosomal Aberrations in a Large Group of Pediatric Patients With Acute Myeloid Leukemia Treated Uniformly According to Trial AML-BFM 98. Journal of clinical oncology 2010, 28: 2682 [PMID: 20439630]
  4. Creutzig U, Zimmermann M, Dworzak M, Urban C, Henze G, Kremens B, Lakomek M, Bourquin JP, Stary J, Reinhardt D: Favourable outcome of patients with childhood acute promyelocytic leukaemia after treatment with reduced cumulative anthracycline doses. British journal of haematology 2010, 149: 399 [PMID: 20230404]

Mye­lo­dys­plas­tic Syn­dro­mes (MDS)

  1. Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Sakamoto KM, Gorr TA, Mehta P, Schmid I, Kropshofer G, Corbacioglu S, Lang PJ, Klein C, Schlegel PG, Heinzmann A, Schneider M, Starý J, van den Heuvel-Eibrink MM, Hasle H, Locatelli F, Sakai D, Archambeault S, Chen L, Russell RC, Sybingco SS, Ohh M, Braun BS, Flotho C, Loh ML: Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet 2010, 42: 794 [PMID: 20694012]


Lymphoblastic Lymphoma-Relapse

  1. Burkhardt B, Reiter A, Landmann E, Lang P, Lassay L, Dickerhoff R, Lakomek M, Henze G, von Stackelberg A: Poor outcome for children and adolescents with progressive disease or relapse of lymphoblastic lymphoma: a report from the berlin-frankfurt-muenster group. Journal of clinical oncology 2009, 27: 3363 [PMID: 19433688]

Hodgkin-Lymphoma: Al­lo­gen­eic Stem Cell Trans­plan­ta­ti­on

  1. Claviez A, Canals C, Dierickx D, Stein J, Badell I, Pession A, Mackinnon S, Slavin S, Dalle JH, Chacón MJ, Sarhan M, Wynn RF, Suttorp M, Dini G, Sureda A, Schmitz N, Lymphoma and Pediatric Diseases Working Parties: Allogeneic hematopoietic stem cell transplantation in children and adolescents with recurrent and refractory Hodgkin lymphoma: an analysis of the European Group for Blood and Marrow Transplantation. Blood 2009, 114: 2060 [PMID: 19498021]

Referring to above publications, there are two comments by:
Nachman J. Allotransplantation in pediatric HL. Blood 114: 2008-09, 2009

answered by:
Schmitz N, Sureda A, Dini G, Claviez A. Allogeneic transplantation for children and adolescents with Hodgkin lymphoma. Blood 114: 4605-6, 2009 Blood Online



  1. Rutkowski S, Cohen B, Finlay J, Luksch R, Ridola V, Valteau-Couanet D, Hara J, Garre ML, Grill J: Medulloblastoma in young children. Pediatr Blood Cancer 2010, 54: 635 [PMID: 20146217]
  2. Rutkowski S, von Hoff K, Emser A, Zwiener I, Pietsch T, Figarella-Branger D, Giangaspero F, Ellison DW, Garre ML, Biassoni V, Grundy RG, Finlay JL, Dhall G, Raquin MA, Grill J: Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis. J Clin Oncol 2010, 28: 4961 [PMID: 20940197]

Other solid tumours

Osteosarcoma and Soft tissue tumours

  1. Jaffe N, Bruland O S, Bielack S: Pediatric and Adolescent Osteosarcoma. Cancer Treatment and Research Vol. 152 2010 [DOI: 10.1007/978-1-4419-0284-9]
  2. Bielack SS, Kempf-Bielack B, Branscheid D, Carrle D, Friedel G, Helmke K, Kevric M, Jundt G, Kühne T, Maas R, Schwarz R, Zoubek A, Jürgens H: Second and subsequent recurrences of osteosarcoma: presentation, treatment, and outcomes of 249 consecutive cooperative osteosarcoma study group patients. Journal of clinical oncology 2009, 27: 557 [PMID: 19075282]
  3. Dantonello TM, Int-Veen C, Harms D, Leuschner I, Schmidt BF, Herbst M, Jürgens H, Scheel-Walter HG, Bielack SS, Klingebiel T, Dickerhoff R, Kirsch S, Brecht I, Schmelzle R, Greulich M, Gadner H, Greiner J, Marky I, Treuner J, Koscielniak E: Cooperative trial CWS-91 for localized soft tissue sarcoma in children, adolescents, and young adults. Journal of clinical oncology 2009, 27: 1446 [PMID: 19224858]

Ewing Sarcoma

  1. Ladenstein R, Pötschger U, Le Deley MC, Whelan J, Paulussen M, Oberlin O, van den Berg H, Dirksen U, Hjorth L, Michon J, Lewis I, Craft A, Jürgens H: Primary Disseminated Multifocal Ewing Sarcoma: Results of the Euro-EWING 99 Trial. Journal of clinical oncology 2010, 28: 3284 [PMID: 20547982]

Rare tumours

Registry of rare tumours

  1. Schneider DT, Brecht IB: Care for rare cancers: improved care requires improved communication. Klinische Padiatrie 2010, 222: 124 [PMID: 20514613]

Late effects and aftercare

Late effects after Hodgkin Lymphoma

  1. Schellong G, Riepenhausen M, Bruch C, Kotthoff S, Vogt J, Bölling T, Dieckmann K, Pötter R, Heinecke A, Brämswig J, Dörffel W: Late valvular and other cardiac diseases after different doses of mediastinal radiotherapy for hodgkin disease in children and adolescents: Report from the longitudinal GPOH follow-up project of the German-Austrian DAL-HD studies. Pediatric blood & cancer 2010, 55: 1145-52. [PMID: 20734400]

Global themes

Trials in Europe

  1. Tallen G, Dworzak M, Gadner H, Masera G, Haupt R, Eggert A, Schrappe M, Biondi A, Vassal G, Creutzig U: More and better cure for an orphan: priorities for future paediatric cancer research in Europe – Meeting report of the EC-funded science-communication project DIRECT “Overcoming Cancer with Research” memo (2009) Vol. 2: 246–254 [DOI: 10.1007/s12254-009-0169-8]
  2. Tallen G, Dworzak M, Gadner H, Masera G, Schrappe M, Biondi A, Vassal G, Pieters R, Jazbec J, Morland B, Creutzig U: Imperative of continual support by the European Community for future advances in paediatric oncology in Europe: meeting report of the EC-funded sciencecommunication project DIRECT “Overcoming Cancer with Research” memo (2009) Vol. 2: 234–245 [DOI: 10.1007/s12254-009-0168-9]

Stemcells from cordblood

  1. Reimann, V: Stammzellen aus Nabelschnurblut in der Transplantations- und regenerativen Medizin. Dtsch Arztebl 2009, 106: 831 [DOI: 10.3238/arztebl.2009.0831]
  2. Klingebiel, T: Was Hoffnung kosten darf: Ist die Einlagerung von autologem Nabelschnurblut nötig und sinnvoll? Dtsch Arztebl 2009, 106: 829 [DOI: 10.3238/arztebl.2009.0829]

"G-CFS induced differentiation" - Fritz-Lampert-Preis 2009 -

  1. Skokowa J, Lan D, Thakur BK, Wang F, Gupta K, Cario G, Brechlin AM, Schambach A, Hinrichsen L, Meyer G, Gaestel M, Stanulla M, Tong Q, Welte K: NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway. Nature medicine 2009, 15: 151 [PMID: 19182797]

Blood Deseases

Fanconi Anaemia

Two mutations in the DNA repair gene RAD51C causing a Fanconi-anaemia-like syndrome with multiple congenital malformations have recently been identified by the research groups of Prof. Helmut Hanenberg and Prof. Heiner Schaal, Children's Hospital and Institute of Virology at the Heinrich-Heine Universität Düsseldorf, Germany, Prof. Christopher Mathew, Guy’s Hospital, London, UK, and of Prof. Detlev Schindler, University of Würzburg, Germany. This breakthrough-discovery was followed by the observation that RAD51C mutations significantly increase susceptibility to breast and ovarian cancer. more...

Press Ddorf_Fanconi.doc

Relevant associated articles:

  1. Vaz F, Hanenberg H, Schuster B, Barker K, Wiek C, Erven V, Neveling K, Endt D, Kesterton I, Autore F, Fraternali F, Freund M, Hartmann L, Grimwade D, Roberts RG, Schaal H, Mohammed S, Rahman N, Schindler D, Mathew CG: Mutation of the RAD51C gene in a Fanconi anemia-like disorder. Nat. Genet 2010, 42: 406 [PMID: 20400963]
  2. Meindl A, Hellebrand H, Wiek C, Erven V, Wappenschmidt B, Niederacher D, Freund M, Lichtner P, Hartmann L, Schaal H, Ramser J, Honisch E, Kubisch C, Wichmann HE, Kast K, Deissler H, Engel C, Müller-Myhsok B, Neveling K, Kiechle M, Mathew CG, Schindler D, Schmutzler RK, Hanenberg H: Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene. Nature genetics 2010, 42: 410 [PMID: 20400964]
  3. González-Murillo A, Lozano ML, Alvarez L, Jacome A, Almarza E, Navarro S, Segovia JC, Hanenberg H, Guenechea G, Bueren JA, Río P: Development of lentiviral vectors with optimized transcriptional activity for the gene therapy of patients with fanconi anemia. Human gene therapy 2010, 21: 623 [PMID: 20001454]
  4. Palagyi A, Neveling K, Plinninger U, Ziesch A, Targosz BS, Denk GU, Ochs S, Rizzani A, Meier D, Thasler WE, Hanenberg H, De Toni EN, Bassermann F, Schäfer C, Göke B, Schindler D, Gallmeier E: Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents. Molecular cancer 2010, 9: 127 [PMID: 20509860]


  1. Kohne E, Kleihauer E: Hämoglobinopathien - eine Langzeitstudie über vier Jahrzehnte. Dtsch Arztebl Int 2010, 107: 65 [DOI: 10.3238/arztebl.2010.0065]
  2. Kulozik E: Hämoglobinopathien nehmen zu. Dtsch Arztebl Int 2010; 107: 63 [DOI: 10.3238/arztebl.2010.0063]